NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*02:01-restricted
TP53 (p53) R175H mutant, with potential antineoplastic activity. Upon isolation, transduction,
expansion ex vivo and re-introduction into the patient, the autologous TP53 R175H
mutant-specific HLA-A*02:01-restricted TCR gene engineered T-lymphocytes NT-175 target
and bind to tumor cells expressing the TP53 R175H mutant. This may lead to cytotoxic
T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the TP53 R175H mutant.
p53, a tumor suppressor gene, is mutated in many tumor cells, resulting in the loss
of apoptosis regulation and abnormal cell proliferation.;