" /> Anti-K-RAS G12V mTCR-transduced Autologous Peripheral Blood Lymphocytes - CISMeF





Preferred Label : Anti-K-RAS G12V mTCR-transduced Autologous Peripheral Blood Lymphocytes;

NCIt synonyms : Anti-K-RAS G12V mTCR-transduced Autologous PBLs; Anti-KRAS G12V mTCR-transduced Autologous Peripheral Blood Lymphocytes;

NCIt definition : Autologous peripheral blood lymphocytes (PBLs) transduced with an HLA class I histocompatibility antigen A*11:01 (HLA-A1101)-restricted murine T-cell receptor (mTCR) that recognizes the glycine to valine point mutation at position 12 (G12V) variant of K-RAS, with potential antineoplastic activity. HLA-A1101 positive PBLs are harvested from a K-RAS G12V-expressing cancer patient and transfected with a retroviral vector that encodes anti-K-RAS G12V mTCR. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-K-RAS G12V mTCR-expressing PBLs target and bind to K-RAS G12V-overexpressing tumor cells, which results in both cytokine secretion and tumor cell lysis. K-RAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutation of K-RAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.;

NCI Metathesaurus CUI : CL541379;

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15/05/2024


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