Preferred Label : WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H / K-HELP-MUC1-22 Peptide-loaded Autologous
Dendritic Cells;
NCIt synonyms : WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H / K-HELP-MUC1-22 Peptide-loaded Autologous
DCs;
NCIt definition : A preparation of autologous dendritic cells (DCs) pulsed with helper/killer-hybrid
epitope long peptides (H/K-HELP) of Wilms tumor 1 (WT1 H/K-HELP), survivin, melanoma-associated
antigen 4 (MAGE-4) and human mucin 1-22 (Muc1-22), with potential immunomodulating
and antineoplastic activities. Upon administration of WT1-H/K-HELP-survivin-H/K-HELP-MAGE-A4-H
/ K-HELP-Muc1-22 peptide-loaded autologous DCs may stimulate the host immune system
to mount an anti-tumoral cytotoxic T lymphocyte (CTL), T-helper (Th), and antibody
responses against WT1-, survivin-, MAGE-4- and Muc1-22-expressing cancer cells, resulting
in tumor cell lysis. WT1, survivin, MAGE-4 and Muc-1-22, tumor-associated antigens
(TAAs), are overexpressed on a variety of cancer cells. The DCs loaded with the long
fusion polypeptides, comprising of one or more helper epitopes and killer epitopes,
may enhance antigen-specific CTL and Th cell production more efficiently than when
the DCs are loaded with a mixture of helper epitope and killer epitope.;
NCI Metathesaurus CUI : CL1412811;
Origin ID : C175443;
UMLS CUI : C5446525;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
