Autologous Anti-CD19 Chimeric Antigen Receptor T-cells C-CAR011

Preferred Label : Autologous Anti-CD19 Chimeric Antigen Receptor T-cells C-CAR011;

NCIt synonyms : Autologous CD19-specific CAR-T Cells C-CAR011; Autologous Anti-CD19 CAR-T Cells C-CAR011; Autologous Anti-CD19 CART Cells C-CAR011;

NCIt definition : A proprietary preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a second-generation chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed, costimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T-cells C-CAR011 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.;

Molecule name : C-CAR011;

NCI Metathesaurus CUI : CL539127;

Details

Origin ID

C141050;

UMLS CUI

C4683473;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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