" /> Anti-HLA-A2/NY-ESO-1 TCR-transduced Autologous T Lymphocytes - CISMeF





Preferred Label : Anti-HLA-A2/NY-ESO-1 TCR-transduced Autologous T Lymphocytes;

NCIt synonyms : Autologous Anti-HLA-A2/NY-ESO1 TCR-transduced T Lymphocytes; Autologous HLA-A2/NY-ESO-1-specific TCR Gene-transduced T-lymphocytes; Anti-HLA-A2/NY-ESO1 TCR-transduced Autologous T cells;

NCIt definition : Autologous human peripheral blood T-lymphocytes transduced with a lentiviral or retroviral vector encoding a human leukocyte antigen A2 (HLA-A2) restricted anti-cancer-testis antigen 1 (NY-ESO-1) T-cell receptor (TCR) gene, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and re-introduction into the patient, the anti-HLA-A2/NY-ESO-1 TCR-transduced autologous T lymphocytes recognize and bind to NY-ESO-1/HLA-A2-positive tumor cells. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types.;

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10/05/2025


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