NCIt definition : A cancer vaccine composed of a combination of the injectable formulations S-488210,
which contains the three HLA-A*02:01-restricted peptides up-regulated lung cancer
10 (lymphocyte antigen 6K; LY6K; URLC10), cell division cycle-associated protein 1
(kinetochore protein Nuf2; NUF2; CDCA1) and insulin-like growth factor 2 mRNA-binding
protein 3 (IGF2BP3; KOC1) and S-488211, which contains the two HLA-A*02:01-restricted
peptides DEP domain-containing protein 1A (DEPDC1) and M-phase phosphoprotein 1 (kinesin-like
protein KIF20B; MPHOSPH1), with potential immunostimulatory and antitumor activities.
Upon administration, multipeptide vaccine S-588210 may stimulate a cytotoxic T-lymphocyte
(CTL) response against tumor cells expressing KOC1, CDCA1, URLC10, DEPDC1 or MPHOSPH1
peptides, resulting in tumor cell lysis and decreased tumor growth.;