Preferred Label : Autologous Alpha-PNE Switchable CAR-T Cells CLBR001 and CD19-specific Adapter Molecule
SWI019;
NCIt synonyms : CLBR001 SWI019; CLBR001 Plus SWI019; Autologous Alpha-PNE Switchable CAR-T Cells CLBR001/CD19-specific Adapter Molecule
SWI019; CLBR001/SWI019;
NCIt definition : A combination of CLBR001, a preparation of autologous T-lymphocytes that has been
genetically engineered to express a switchable, alpha-peptide neo-epitope (PNE) chimeric
antigen receptor (CAR) with a binding domain that can recognize a 14 aa peptide epitope,
or PNE, of an antigen-specific adapter molecule, and SWI019, a preparation of adapter
molecules consisting of an antibody fragment (Fab) targeting CD19 linked to a PNE
recognizable by CLBR001, with potential immunomodulating and antineoplastic activities.
Upon administration of autologous alpha-PNE switchable CAR-T cells CLBR001 and CD19-specific
adapter molecule SWI019, the Fab moiety of SWI019 targets and binds to tumor cells
expressing CD19, and the PNE of SWI019 binds to the binding domain of CLBR001, thereby
activating CLBR001. This induces selective toxicity in and causes lysis of CD19-expressing
tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed
in B-cell lineage malignancies.;
NCI Metathesaurus CUI : CL1662652;
Origin ID : C179912;
UMLS CUI : C5555947;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
