Preferred Label : Autologous EGFRt/19-28z/4-1BBL CAR T-Lymphocytes;
NCIt synonyms : CD19-Targeted EGFRt/19-28z/4-1BBL Armored CAR Modified T Cells; Autologous EGFRt/19-28z/4-1BBL CAR T Cells; CD19-Targeted EGFRt/19-28z/4-1BBL Armored Chimeric Antigen Receptor Modified T-Cells;
NCIt definition : Genetically modified autologous T-lymphocytes transduced with a replication incompetent
retroviral vector expressing both tumor necrosis factor ligand superfamily (TNFSF)
member 9 (TNFSF9; 4-1BBL) and a chimeric T cell antigen receptor (CAR) consisting
of an anti-CD19 scFv (single chain variable fragment), fused to the extracellular,
transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor
CD28, the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta)
(19-28z), and a truncated form of the human epidermal growth factor receptor (EGFRt),
with potential immunostimulating and antineoplastic activities. Upon intravenous administration,
autologous EGFRt/19-28z/4-1BBL CAR T-lymphocytes are directed to CD19-expressing tumor
cells, which induces selective toxicity in CD19-expressing tumor cells. These cells
also express 4-1BBL, a secreted protein and member of the TNFSF of growth factors,
that induces proliferation of T-cells and may help reverse immunosuppression in the
tumor environment. CD19 antigen is a B-cell specific cell surface antigen expressed
in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain
enhances activation and signaling after recognition of CD19. The inclusion of the
CD28 signaling domain may increase proliferation of T-cells and antitumor activity
compared to the inclusion of the CD3-zeta chain alone. Devoid of both ligand binding
domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of
the administered, transduced T-cells and can promote elimination of those cells through
a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response.;
NCI Metathesaurus CUI : CL520584;
Origin ID : C133189;
UMLS CUI : C4524459;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
