NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to
express a chimeric antigen receptor (CAR) targeting the human tumor-associated antigen
(TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily
member 17; TNFRSF17), with potential antineoplastic activity. Upon administration,
the autologous anti-BCMA CAR T-cells PHE885 recognize and induce selective toxicity
against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor
for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF),
is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a
key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and
is overexpressed on malignant plasma cells.;