NCIt synonyms : pBCAR3-phosphopeptide Plus Tet Vaccine;
NCIt definition : A vaccine composed of a phosphorylated peptide from the tumor associated antigen breast
cancer anti-estrogen resistance-3 (BCAR3) and a tetanus-derived peptide, with potential
immunomodulating and antineoplastic activities. Upon administration of pBCAR3 phosphopeptide-tetanus
peptide vaccine, the pBCAR3 phosphopeptide may stimulate the immune system to mount
a cytotoxic T-lymphocyte (CTL) response against phosphopeptide-containing tumor cells.
The tetanus peptide serves as an immunoadjuvant and induces a helper T-cell response,
which may help stimulate an immune response against the pBCAR3-expressing melanoma
tumor cells. BCAR3 is upregulated in a variety of cancer cells.;