Autologous Tn-MUC1-specific CAR T-lymphocytes

Preferred Label : Autologous Tn-MUC1-specific CAR T-lymphocytes;

NCIt synonyms : Autologous Tn-MUC1-specific CAR T Cells; Anti-TnMUC1-CAR-expressing Autologous T-lymphocytes; Autologous TnMUC1-targeted Genetically-Modified CAR T Cells; Autologous Anti-TnMUC1-CAR-expressing T-lymphocytes; Autologous CART-TnMUC1 Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Tn glycoform of mucin-1 (Tn-MUC1; TnMUC1), with potential antineoplastic and immunostimulating activities. Upon re-introduction into the patient, the autologous Tn-MUC1-specific CAR T-lymphocytes specifically recognize and induce selective toxicity in TnMUC1-expressing tumor cells. TnMUC1 is overexpressed in certain tumor types.;

NCI Metathesaurus CUI : CL978618;

Details

Origin ID

C165433;

UMLS CUI

C5237176;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Mucin-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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