Preferred Label : Adenovirus Encoding Rat HER-2/neu;
NCIt synonyms : Adenovirus Encoding Rat Her-2 neu;
NCIt definition : A replication-defective oncolytic adenovirus, encoding rat Her-2/neu (ErbB-2), with
potential antineoplastic activity. Upon administration, adenovirus encoding rat HER-2/neu
may induce an immune response against tumor cells expressing the HER-2/neu antigen,
which may result in the immune-mediated inhibition of tumor cell proliferation and
tumor cell death. Her-2/neu, a tumor-associated antigen and member of the epidermal
growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in various
tumor cell types.;