NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a vector
expressing a chimeric antigen receptor (CAR) containing a humanized single chain variable
fragment (scFv) specific for the tumor-associated antigen (TAA) B-cell maturation
antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) that
is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling
domain of CD3zeta (CD3z), with potential immunostimulating and antineoplastic activities.
Upon administration, zevorcabtagene autoleucel specifically recognize and induce selective
toxicity against BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a
receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor
(BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and
plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found
on the surfaces of B-cells and is overexpressed on malignant plasma cells.;