Vaccinia-Tyrosinase Vaccine

Preferred Label : Vaccinia-Tyrosinase Vaccine;

NCIt synonyms : rV-TYR Vaccine; VACTYROS; Recombinant Vaccinia-Tyrosinase; Recombinant Vaccinia-Tyrosinase Vaccine; rV-TYR;

NCIt definition : A vaccine consisting of recombinant vaccinia virus, based on the modified vaccinia virus Ankara (MVA) that encodes the melanoma-associated antigen tyrosinase. Vaccination with vaccinia-tyrosinase may stimulate the host immune system to mount a cytotoxic T-cell response against tumor cells expressing tyrosinase. Tyrosinase is a melanoma-specific differentiation agent that catalyzes the synthesis of the melanin precursor L-3,4-dihydroxyphenylalanine (L-DOPA).;

NSC code : 702140;

Details

Origin ID

C2531;

UMLS CUI

C0796657;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_abnormal_cell
- Melanoma Cell [NCIt concept]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tyrosinase [NCIt concept]
is_component_of_chemotherapy_regimen
- Fowlpox Virus Vaccine/Interleukin-2/Vaccinia-Tyrosinase Vaccine [NCIt concept]
- Fowlpox-Tyrosinase Vaccine/Interleukin-2/Vaccinia-Tyrosinase Vaccine [NCIt concept]
- Interleukin-2/Vaccinia-Tyrosinase Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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