NCIt definition : A preparation of autologous T-lymphocytes genetically engineered to express a defined
gamma delta T-cell receptor (TCR), with potential immunomodulating and antineoplastic
activities. Upon administration of the autologous gamma delta TCR-expressing T-cells
TEG002, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor
cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte
(CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the
activation of the immune system and do not require major histocompatibility complex
(MHC)-mediated antigen presentation to exert their cytotoxic effect.;