NCIt synonyms : Anti-hCD70 CAR autologous PBLs; Anti-hCD70-CAR Retroviral Vector-transduced Autologous Peripheral Blood Lymphocytes; Anti-hCD70 Autologous CAR-transduced T Cells;
NCIt definition : A preparation of autologous human peripheral blood lymphocytes (PBLs) transduced with
a retroviral vector encoding for a T-cell chimeric antigen receptor (CAR) gene specific
for the human cluster of differentiation 70 (CD70), with potential immunostimulatory
and antineoplastic activities. Autologous PBLs from a patient with CD70-positive cancer
are transduced with a retroviral vector that encodes the CAR gene specific for CD70.
After expansion in culture and reintroduction into the patient, anti-hCD70-CAR retroviral
vector-transduced autologous PBLs bind to the CD70 antigen on tumor cell surfaces;
subsequently, CD70-expressing tumor cells are lysed. CD70, the ligand for the costimulatory
receptor CD27, is overexpressed on the surfaces of various cancer cell types.;