NCIt synonyms : pIRS2-phosphopeptide Plus Tet Vaccine;
NCIt definition : A vaccine composed of a phosphorylated peptide from the tumor associated antigen insulin
receptor substrate-2 (IRS2) and a tetanus-derived peptide, with potential immunomodulating
and antineoplastic activities. Upon administration of pIRS2 phosphopeptide-tetanus
peptide vaccine, the pIRS2 phosphopeptide may stimulate the immune system to mount
a cytotoxic T-lymphocyte (CTL) response against phosphopeptide-containing tumor cells.
The tetanus peptide serves as an immunoadjuvant and induces a helper T-cell response
which may help stimulate an immune response against the pIRS2-expressing melanoma
tumor cells. IRS2 is upregulated in a variety of cancer cells.;