NCIt definition : A preparation of human autologous T-lymphocytes transduced with a viral vector encoding
for a T-cell receptor (TCR) specific for a human hepatitis B virus (HBV) surface antigen
(HBsAg), with potential antineoplastic activity. Following administration, the autologous
HBV antigen specific TCR-redirected autologous T-lymphocytes recognize and bind to
the HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated
elimination of HBV antigen-positive cancer cells. HBV antigens are found on HBV-positive
cells and HPV-induced hepatocellular carcinoma (HCC).;