Preferred Label : Autologous Nectin-4/FAP-targeted CAR-T Cells;
NCIt synonyms : Autologous Anti-nectin-4/Anti-FAP CAR-T Cells; Autologous Nectin4/FAP-targeted CAR-T Cells; Autologous Anti-nectin-4/FAP CAR-T Cells;
NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen
receptor (CAR) specific for the tumor-associated antigen (TAA) nectin-4 and cell surface
protein fibroblast activation protein (FAP), and additionally an inducible expression
cassette encoding transgenic interleukin (IL) 7 (IL-7) or 12 (IL-12), with potential
immunostimulating and antineoplastic activities. Upon intratumoral administration,
the autologous nectin-4/FAP-targeted CAR-T cells target and bind to nectin-4-expressing
tumor cells and FAP-expressing cancer associated fibroblasts (CAFs). This results
in a cytotoxic T-lymphocyte (CTL) response against nectin-4-expressing tumor cells
and FAP-expressing CAFs, leading to cell lysis of these cells. Upon the binding to
nectin-4 and FAP and the activation of the CAR-T cells, cytokine IL-7 or IL-12 is
also released. This further augments the immune responses against the tumor cells,
which may include the attack of nectin-4-negative tumor cells by tumor necrosis factor
alpha (TNFa). Nectin-4, a TAA belonging to the nectin family, is overexpressed in
a variety of cancers, including breast, bladder, lung and pancreatic cancer. FAP,
a cell surface glycoprotein, is overexpressed on CAFs but minimally expressed on normal,
healthy cells.;
NCI Metathesaurus CUI : CL1406512;
Origin ID : C172386;
UMLS CUI : C5421268;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
