" /> Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T Cells - CISMeF





Preferred Label : Autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T Cells;

NCIt synonyms : Autologous CD19R:CD28:lentiviral/EGFRt T Cells;

NCIt definition : A preparation of genetically modified autologous central memory (Tcm) enriched T-cells transduced with a replication incompetent lentiviral vector expressing a chimeric antigen receptor (CAR), containing a CD28 signaling domain fused to both CD3 zeta, which targets the CD19 antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. The costimulatory signaling domain enhances proliferation of T cells and antitumor activity.;

NCI Metathesaurus CUI : CL446451;

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15/05/2024


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