Autologous Anti-NKG2DLs CAR-T Cells LEU011

Preferred Label : Autologous Anti-NKG2DLs CAR-T Cells LEU011;

NCIt synonyms : Autologous NKG2DLs-targeting CAR T-cells LEU011; Autologous NKG2D Ligands-targeting CAR T-cells LEU011; Autologous Anti-NKG2DL CAR T-cells LEU 011;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting natural-killer group 2, member D ligands (NKG2DLs), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-NKG2DLs CAR-T cells LEU011 specifically recognize and induce selective toxicity in tumor cells expressing NKG2DLs. Ligands for NKG2D, such as MHC class I chain-related protein A (MICA), MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on various cancer cell types, but are not expressed on most normal, healthy cells.;

Molecule name : LEU-011; LEU 011;

NCI Metathesaurus CUI : CL1928594;

Details

Origin ID

C206254;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients