Preferred Label : Autologous NY-ESO-1/LAGE-1a-specific HLA-A*02:01-restricted TCR-expressing T-lymphocytes
MDG1015;
NCIt synonyms : Autologous NY-ESO-1/LAGE-1a-specific HLA-A*02:01-restricted TCR/PD-1-4-1BB Costimulatory
Switch Protein-expressing T-cells MDG1015; Autologous NY-ESO-1/LAGE-1a-specific HLA-A*02:01-restricted TCR-T Cells MDG1015;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to
express a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*02:01-restricted
cancer-testis antigens (CTAs) NY-ESO-1 and L antigen family member 1 isoform A (LAGE-1A;
LAGE-A1; CT6.2a), and a programmed cell death protein 1 (PD-1; PDCD1; CD279)-4-1BB
(CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9) costimulatory
switch protein (CSP), with potential immunomodulating and antineoplastic activities.
Upon reintroduction into the patient, autologous NY-ESO-1/LAGE-1a-specific HLA-A*02:01-restricted
TCR-expressing T-lymphocytes MDG1015 specifically targets and binds to NY-ESO-1 and/or
LAGE-1A expressed on tumor cells. This may lead to cytotoxic T-lymphocyte (CTL)-mediated
elimination of tumor cells expressing NY-ESO-1 and/or LAGE-1A. In addition, upon binding
of the TCR-T cells MDG1015 to NY-ESO-1 and/or LAGE-1A expressed on tumor cells, the
PD-1-4-1BB CSP is activated. This abrogates PD-1-mediated signaling in T-cells and
PD-1-mediated T-cell inhibition, and activates 4-1BB signaling locally in the tumor
microenvironment (TME), which enhances the activity and persistence of the TCR-T cells
MDG1015. NY-ESO-1 and LAGE-1A, members of the CTA family, are overexpressed on the
surface of various tumor cell types; they share a specific HLA-A*02:01 epitope, 157-165,
which is expressed on certain tumor cell types while its expression is not found on
normal, healthy cells.;
Molecule name : MDG-1015; MDG 1015;
Origin ID : C213073;
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- chemical_or_drug_has_physiologic_effect
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