CD33-specific CAR Lentiviral Vector-transduced Autologous T-lymphocytes

Preferred Label : CD33-specific CAR Lentiviral Vector-transduced Autologous T-lymphocytes;

NCIt synonyms : Autologous Anti-CD33 CAR-T Cells; Autologous Anti-CD33 Chimeric Antigen Receptor T Cells; Autologous CD33-CAR-T Cells;

NCIt definition : Autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR lentiviral vector-transduced autologous T-lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells.;

NCI Metathesaurus CUI : CL551135;

Details

Origin ID

C148530;

UMLS CUI

C4725105;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Myeloid Cell Surface Antigen CD33 [NCIt concept]

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