NCIt definition : Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral
vector encoding T-cell receptors (TCRs) specific for a patient's individual and unique
mutated antigens, with potential immunostimulating and antineoplastic activities.
Tumor cells are analyzed to identify and isolate specific mutated tumor-associated
antigens (TAAs) that are expressed by the patient's tumor cells; then T-cell receptor
coding sequences are engineered to target the patient's TAAs and inserted into retroviral
vectors. After transduction, expansion in culture, and reintroduction into the patient,
neoantigen-specific TCRs retroviral vector-transduced autologous PBLs recognize and
bind to tumor cells expressing the patient's neoantigens, which results in a specific
cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor
cells.;