" /> Autologous PBLs Retrovirally-transduced with TCRs Targeting Neoantigens - CISMeF





Preferred Label : Autologous PBLs Retrovirally-transduced with TCRs Targeting Neoantigens;

NCIt synonyms : Neoantigen-reactive TCRs-transduced Autologous PBLs; Autologous PBLs Expressing Mutated Neoantigen-specific T-Cell Receptors; Autologous Peripheral Blood Lymphocytes Retrovirally-transduced with TCRs Targeting Neoantigens; Neoantigen-specific TCRs Gene-transduced Autologous PBLs;

NCIt definition : Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding T-cell receptors (TCRs) specific for a patient's individual and unique mutated antigens, with potential immunostimulating and antineoplastic activities. Tumor cells are analyzed to identify and isolate specific mutated tumor-associated antigens (TAAs) that are expressed by the patient's tumor cells; then T-cell receptor coding sequences are engineered to target the patient's TAAs and inserted into retroviral vectors. After transduction, expansion in culture, and reintroduction into the patient, neoantigen-specific TCRs retroviral vector-transduced autologous PBLs recognize and bind to tumor cells expressing the patient's neoantigens, which results in a specific cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells.;

NCI Metathesaurus CUI : CL544885;

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24/05/2025


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