NCIt definition : A preparation of human autologous T-lymphocytes that are genetically modified to express
a T-cell receptor (TCR) specific for the human cancer-testis antigen NY-ESO-1 and
the CD8alpha co-receptor, with potential immunostimulating and antineoplastic activities.
Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction
into the patient, the autologous anti-NY-ESO-1 TCR/CD8alpha-expressing T-cells GSK3901961
recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific
cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1,
a tumor-associated antigen (TAA), is found in normal testis and on the surface of
various tumor cell types. Co-expression of CD8alpha may broaden the immune response
against tumors and increase antitumor activity by converting CD4 helper T-cells into
CD8 cytotoxic T-cells.;