NCIt synonyms : Autologous Anti-CD19 CAR T Cells CRC01; Autologous Anti-CD19 CAR-T Cells CRC01;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA)
CD19, with potential immunostimulating and antineoplastic activities. Upon administration,
anbalcabtagene autoleucel targets and binds to CD19-expressing tumor cells. This results
in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and
tumor cell lysis. CD19 is a B-cell-specific cell surface antigen overexpressed in
B-cell lineage tumors.;