" /> Anti-EGFRvIII-CAR-CD3/EGFR BiTE-transduced Autologous T-lymphocytes CARv3-TEAM-E - CISMeF





Preferred Label : Anti-EGFRvIII-CAR-CD3/EGFR BiTE-transduced Autologous T-lymphocytes CARv3-TEAM-E;

NCIt synonyms : Autologous CARv3-TEAM-E-transduced T-cells; Autologous CARv3-TEAM-E-transduced T-lymphocytes;

NCIt related terms : nti-EGFRvIII-CAR-CD3/EGFR BiTE-transduced Autologous T-lymphocytes CARv3-TEAM-E;

NCIt definition : A preparation of autologous human T-lymphocytes transduced with a CARv3-TEAM-E lentiviral vector encoding for an anti-epidermal growth factor receptor (EGFR) variant III (EGFRvIII) mutant chimeric T cell receptor (chimeric antigen receptor or CAR) and a T cell engaging antibody molecule (TEAM) which comprises a bispecific T-cell engager (BiTE) against EGFR and the T-cell signaling domain CD3, with potential immunostimulatory and antineoplastic activities. Upon administration via Ommaya reservoir of the anti-EGFRvIII CAR-CD3/EGFR BiTE-transduced autologous T-lymphocytes CARv3-TEAM-E, the lymphocytes bind to the EGFRvIII antigen on tumor cell surfaces and the BiTE binds to CD3 on bystander T-cells; thereby killing EGFRvIII-expressing tumor cells through the administered CAR-T cells and wild-type (WT) EGFR-expressing tumor cells by bystander T-cells, respectively. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types and absent in normal, healthy cells; it plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance.;

NCI Metathesaurus CUI : CL1914098;

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15/05/2024


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