" /> Autologous Anti-CD19 CAR-T Cells TBI-1501 - CISMeF





Preferred Label : Autologous Anti-CD19 CAR-T Cells TBI-1501;

NCIt synonyms : CAR19 T-lymphocytes TBI-1501; Anti-CD19-CAR T-cells TBI-1501; Autologous Anti-CD19 Chimeric Antigen Receptor T Cells TBI-1501;

NCIt definition : Autologous T-lymphocytes that have been transduced, via a proprietary technology involving a recombinant human fibronectin fragment to enhance transduction efficiency, with a retroviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to co-stimulatory molecules, with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD19-CAR-expressing autologous T-lymphocytes TBI-1501 target and bind to CD19-expressing neoplastic B-cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increase proliferation and activation of T-cells.;

Molecule name : TBI-1501;

NCI Metathesaurus CUI : CL552174;

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10/05/2024


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