Liposomal MUC1/PET-lipid A Vaccine ONT-10 - CISMeF
Liposomal MUC1/PET-lipid A Vaccine ONT-10NCIt concept
Preferred Label : Liposomal MUC1/PET-lipid A Vaccine ONT-10;
NCIt definition : A cancer vaccine comprised of a 43 amino acid epitope from glycoprotein MUC1 (mucin
1) and the synthetic Toll-like receptor 4 (TLR-4) agonist PET lipid A encapsulated
in cholesterol/dipalmitoylphosphatidylcholine (DPPC)/dimyristoylphosphatidylglycerol
(DMPG) liposomes, with potential immunostimulatory and antineoplastic activities.
The MUC1 epitope is composed of two 20 amino glycosylated VNTR (various number tandem
repeats) from human MUC1A and including 6 glycosylated sites modified by Tn (alfa-N-acetyl-D-galactosamine).
Immunization of liposomal MUC1/PET-lipid A vaccine ONT-10 results in an antibody as
well as a cytotoxic T-lymphocyte (CTL) response against hypoglycosylated MUC1 expressing
tumor cells. The tumor associated antigen MUC1, a type I transmembrane protein, is
overexpressed and aberrantly glycosylated in a variety of tumor cells. As a vaccine
adjuvant, PET lipid A, also known as penta erythritol lipid A, stimulates both cellular
and humoral responses to the vaccine antigen.;