NCIt synonyms : TRBC1-targeting CAR T Cells AUTO4; Anti-TRBC1 CAR T-cells AUTO4; RQR8/TRBC1 CAR T Cells AUTO4;
NCIt definition : Autologous human T-lymphocytes that are genetically engineered to express a chimeric
antigen receptor (CAR) containing an anti-T-cell receptor beta constant 1 (TRBC1;
T-cell receptor beta-1 chain C region) single chain variable fragment (scFv) and the
co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex
(CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon administration,
anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing autologous T-lymphocyte cells AUTO4 targets
and binds to the TRBC1 expressed on tumor cell surfaces. Subsequently, TRBC1-expressing
tumor cells are lysed. In addition, AUTO4 carries the universal RQR8 safety off switch,
which allows selective removal of the T-cells through both complement-dependent cytotoxicity
(CDC) and antibody-dependent cellular cytotoxicity (ADCC) following administration
of rituximab if unacceptable side-effects occur.;