Preferred Label : Anti-NY-ESO1 TCR-transduced Autologous CD62L -derived T-Lymphocytes;
NCIt synonyms : Autologous CD62L -derived T Lymphocytes Transduced With NY-ESO-1-specific TCR;
NCIt definition : Human autologous CD62L-positive T-lymphocytes transduced with a retroviral vector
encoding a T cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1,
with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes,
expansion ex vivo, transduction, and reintroduction into the patient, the anti-NY-ESO1
TCR-transduced autologous CD62L -derived T-Lymphocytes bind to NY-ESO-1-overexpressing
tumor cells. This may result in cytotoxic T-lymphocyte (CTL)-mediated elimination
of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor associated antigen (TAA), is
found in normal testis and on the surface of various tumor cell types. CD62L, also
called L-selectin, is a lymphoid homing receptor and differentiation marker and is
expressed on a subset of CD8-positive T-lymphocytes; it is involved in the migration
of T-lymphocytes to lymph nodes and may improve the efficacy for ex vivo-expanded
T-cells following adoptive cell therapy.;
NCI Metathesaurus CUI : CL472223;
Origin ID : C114295;
UMLS CUI : C3831512;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
