" /> Autologous Anti-CD19 TAC-T cells TAC01-CD19 - CISMeF





Preferred Label : Autologous Anti-CD19 TAC-T cells TAC01-CD19;

NCIt synonyms : CD19-targeted T Cell Antigen Coupler TAC01-CD19;

NCIt definition : A preparation of autologous T-lymphocytes genetically engineered with a T cell Antigen Coupler (TAC), comprising of a domain that targets the tumor-associated antigen (TAA) cluster of differentiation 19 (CD 19) and another domain that binds to the endogenous T cell receptor (TCR), anchored in the membrane via the CD4 co-receptor domain, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 TAC-T cells TAC01-CD19 targets and binds to CD19-expressing tumor cells and activates TCR-mediated signaling pathways, leading to T cell-mediated killing of CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.;

Molecule name : TAC01 CD19; TAC01-CD19;

NCI Metathesaurus CUI : CL1406193;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
10/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.