Autologous Gamma-retroviral MSGV1 139 scFv EGFRvIII CAR Gene-modified T Cells - CISMeF
Autologous Gamma-retroviral MSGV1 139 scFv EGFRvIII CAR Gene-modified T CellsNCIt concept
Preferred Label : Autologous Gamma-retroviral MSGV1 139 scFv EGFRvIII CAR Gene-modified T Cells;
NCIt synonyms : MSGV1-EGFRvIII-specific CAR-transduced Autologous T Lymphocytes; Gamma-retroviral MSGV1 139 scFv EGFRvIII CAR Gene-modified Autologous T-lymphocytes; MSGv1-EGFRvIII-CAR Autologous T Cells;
NCIt definition : A preparation of autologous T-lymphocytes transduced with the gamma retroviral vector
MSGV1 expressing a chimeric T-cell antigen receptor (CAR) consisting of a single-chain
variable fragment (scFv) from a specific antibody clone (mAb139) that targets a mutant
form of epidermal growth factor receptor (EGFR) known as variant III (EGFRvIII; EGFR-vIII),
with potential antineoplastic activity. Upon intratumoral administration, the gamma-retroviral
MSGV1 139 scFv EGFRvIII CAR gene-modified T-cells specifically target and bind to
tumor cells expressing EGFRvIII, leading to selective cytotoxicity in EGFRvIII-expressing
tumor cells. EGFRvIII, a tumor-associated antigen (TAA) encoded by an in-frame deletion
of exons 2-7 in the EGFR gene, is specifically overexpressed by a subset of tumor
cells and is not expressed in normal, healthy cells. It plays a key role in tumor
cell proliferation, tumor angiogenesis and radio- and chemoresistance.;