Autologous Anti-CLDN6 CAR-NK Cells

Preferred Label : Autologous Anti-CLDN6 CAR-NK Cells;

NCIt synonyms : Autologous Anti-CLDN6-CAR-NKs; Autologous CLDN6-CAR-NK Cells; Autologous Claudin 6-targeted CAR-NK Cells;

NCIt definition : A preparation of autologous natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the cell surface protein claudin 6 (CLDN6), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CLDN6 CAR-NK cells target and bind to CLDN6 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing CLDN6. CLDN6, a tight-junction protein and embryonic antigen, is expressed on a variety of tumor cells but is not expressed on normal, healthy adult cells.;

NCI Metathesaurus CUI : CL1793637;

Details

Origin ID

C188377;

UMLS CUI

C5707731;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Claudin-6 [NCIt concept]

Keyword's position in hierarchy(ies) :

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