Autologous Anti-CD38 A2 CAR2-expressing T-cells

Preferred Label : Autologous Anti-CD38 A2 CAR2-expressing T-cells;

NCIt synonyms : Autologous CD38-A2 CAR2-expressing T-lymphocytes; Autologous Anti-CD38 A2 CAR2 T-cells; Autologous CAR2 Anti-CD38 A2 T-lymphocytes; Autologous CAR2 Anti-CD38 A2 CAR T-cells;

NCIt definition : A preparation of genetically modified autologous T-cells expressing a chimeric antigen receptor recognizing the tumor-associated antigen (TAA) cluster of differentiation 38 (CD38), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD38 A2 CAR2-expressing T-cells are directed to and induce selective toxicity in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis.;

NCI Metathesaurus CUI : CL562999;

Details

Origin ID

C156170;

UMLS CUI

C4744619;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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