" /> Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes - CISMeF





Preferred Label : Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes;

NCIt synonyms : Autologous GPC3-CAR T Cells; Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells; Autologous GAP T Cells; GPC3-CAR Transduced Autologous T Cells; Anti-GPC3-scFvGC33-CAR Autologous T Lymphocytes; Glypican 3-specific Chimeric Antigen Receptor-expressing Autologous T Cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from the anti-glypican-3 (GPC3) monoclonal antibody GC33 (scFvGC33), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-scFvGC33-CAR autologous T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells.. GPC3 plays an important role in cellular proliferation and differentiation.;

NCI Metathesaurus CUI : CL520573;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
15/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.