NCIt synonyms : Anti-MUC1 Autologous CAR T Cells; Anti-Mucin1 Autologous CAR T Cells; Anti-MUC1 CAR-transduced Autologous T Cells;
NCIt definition : Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric
antigen receptor (CAR) consisting of a single chain variable fragment (scFv) against
the human tumor-associated epithelial antigen mucin 1 (MUC1), with potential immunomodulating
and antineoplastic activities. Autologous PBLs from a patient with MUC1-positive cancer
are transduced with a retroviral vector that encodes the CAR gene specific for MUC1.
After expansion in culture and reintroduction into the patient, anti-MUC1 CAR-transduced
autologous T-lymphocytes target and induce selective toxicity in MUC1-expressing tumor
cells. MUC-1 is a human, hypoglycosylated tumor-associated antigen (TAA) overexpressed
by epithelial cancer cells.;