Autologous Anti-BCMA CD8 CAR T-cells Descartes-11 - CISMeF
Autologous Anti-BCMA CD8 CAR T-cells Descartes-11NCIt concept
Preferred Label : Autologous Anti-BCMA CD8 CAR T-cells Descartes-11;
NCIt synonyms : Autologous CD8 T-cells Expressing Anti-BCMA CAR Descartes-11;
NCIt definition : A preparation of autologous CD8-positive T-lymphocytes that have been genetically
modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated
antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor
superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic
activities. Upon administration, autologous anti-BCMA CD8 CAR T-cells Descartes-11
specifically recognize and induce selective toxicity in BCMA-expressing tumor cells.
BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand
(APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor
receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is
found on the surfaces of plasma cells and is overexpressed on malignant plasma cells.;
Molecule name : Descartes-011; Descartes-11; Descartes 11;