" /> Autologous Anti-CLL-1-CAR T-lymphocytes KITE-222 - CISMeF





Preferred Label : Autologous Anti-CLL-1-CAR T-lymphocytes KITE-222;

NCIt synonyms : Autologous Anti-CLL-1-CAR T-cells KITE-222; Autologous Anti-CLL1-CAR-T Cells KITE-222; Autologous Anti-CLL1 CAR T Cells KITE-222;

NCIt definition : A preparation of autologous T-lymphocytes expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) C-type-lectin-like molecule-1 (CLL-1; CLL1; C-type lectin domain family 12 member A; CLEC12A), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CLL-1-CAR T-lymphocytes KITE-222 specifically target and bind to CLL-1-expressing tumor cells. This induces selective toxicity in tumor cells that express the CLL-1 antigen. CLL-1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies.;

Molecule name : KITE 222; KITE-222;

NCI Metathesaurus CUI : CL1648048;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
15/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.