" /> Obecabtagene Autoleucel - CISMeF





Preferred Label : Obecabtagene Autoleucel;

NCIt synonyms : AUTO1 CAR-T Cells; Autologous CD19-targeted CAR T-cells AUTO1; Autologous Anti-CD19 CAR T-cells AUTO1; CD19CAR T-cells AUTO1; Autologous Anti-CD19 Chimeric Antigen Receptor T-lymphocytes AUTO1; CD19CAT-41BBZ CAR T-cells AUTO1; Autologous Anti-CD19 Chimeric Antigen Receptor T-cells AUTO1; Obe-cel;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a second-generation chimeric antigen receptor (CAR), CAT-41BBz CAR, targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, obecabtagene autoleucel target and bind to CD19-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells and tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The CAT-41BBz CAR has a faster off-rate compared with FMC63-41BBz CAR. This may minimize cytokine release and reduce toxicities, and enhance persistence of the CAR T-cells.;

UNII : 760HJB0YRD;

Molecule name : AUTO-1; AUTO 1;

NCI Metathesaurus CUI : CL1406598;

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15/05/2024


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