Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART

Preferred Label : Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART;

NCIt synonyms : Autologous Desmoglein-3 CAAR-expressing T-cells DSG3-CAART; DSG3 CAART; Autologous Desmoglein 3 Chimeric Autoantibody Receptor T Cells DSG3-CAART; Autologous DSG3 Chimeric Autoantibody Receptor T-cells DSG3-CAART; Autologous DSG3 CAART DSG3-CAART;

NCIt definition : A preparation of autologous T-lymphocytes that have been engineered to express a chimeric autoantibody receptor (CAAR) containing the autoantigen desmoglein-3 (desmoglein 3; DSG3) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunomodulatory activity. Upon administration, the autologous DSG3 chimeric autoantibody receptor T-cells (CAART) DSG3-CAART specifically recognize and induce selective toxicity in aberrant B-cells expressing DSG3 autoantibodies. This inhibits the production of DSG3 autoantibodies. DSG3 is a protein expressed in desmosomes that plays an important role in cell adhesion. DSG3 autoantibodies are produced and expressed by aberrant B-cells in the autoimmune disease mucosal-dominant pemphigus vulgaris.;

NCI Metathesaurus CUI : CL1771131;

Details

Origin ID

C182441;

UMLS CUI

C5667586;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Desmoglein-3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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