Desmoglein-3 - CISMeF

Preferred Label : Desmoglein-3;

NCIt synonyms : 130 kDa Pemphigus Vulgaris Antigen; Cadherin Family Member 6; PVA; Desmoglein 3; DSG3;

NCIt definition : Desmoglein-3 (999 aa, 108 kDa) is encoded by the human DSG3 gene. This protein plays a role in desmosome-mediated cell-cell adhesion.;

Alternative definition : CDISC: An antigen of the cell-cell adhesion protein encoded by the DSG3 gene. It can be considered as an autoantigen and is commonly associated with autoimmune disease pemphigus vulgaris.;

NCIt note : Desmoglein-3 has been identified as the autoantigen involved in pemphigus vulgaris.;

Details

Origin ID

C101150;

UMLS CUI

C5441614;

OMIM relation
- Desmoglein 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Desmoglein 3 [LOINC component]
- desmoglein 3 [MeSH concept]
- desmoglein 3 [MeSH Descriptor]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- DSG3 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Desmosome [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cadherin Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell-Cell Adhesion Process [NCIt concept]
is_target
- Autologous Desmoglein-3 Chimeric Autoantibody Receptor T-cells DSG3-CAART [NCIt concept]

Keyword's position in hierarchy(ies) :

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