NCIt definition : A peptide vaccine containing amino acids residues from 419 through 427 of the latent
membrane protein-2 (LMP-2) of the Epstein-Barr virus (EBV) with potential immunostimulating
and antineoplastic activities. LMP-2, an EBV transmembrane protein, is expressed in
various malignancies including nasopharyngeal cancer and EBV-positive Hodgkin disease.
Vaccination with the LMP-2:49-427 peptide may boost the immune system to mount a specific
cytotoxic T-lymphocyte response against LMP-2 producing cells, resulting in cell lysis
and inhibition of cancer cell proliferation.;