Preferred Label : CD19CAR-CD3zeta-4-1BB-CD28-expressing Autologous T-Lymphocytes;
NCIt definition : Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric
antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment)
coupled to three co-stimulatory signaling domains derived from CD28, 4-1BB (CD137),
and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta), with potential
immunomodulating and antineoplastic activities. Upon transfusion, the CD19CAR-CD3zeta-4-1BB-CD28-expressing
autologous T-lymphocytes direct the T-lymphocytes to CD19-expressing tumor cells and
induce their selective toxicity. CD28, a T-cell surface-associated co-stimulatory
molecule, is required for T-cell activation, proliferation, and survival. The 4-1BB
co-stimulatory molecule signaling domain enhances activation and signaling after recognition
of CD19. CD3-zeta is a transmembrane signaling adaptor polypeptide that regulates
the assembly of TCR complexes, modulates the expression of the complex on the cell
surface and plays a key role in antigen recognition. CD19 antigen, a B-cell specific
cell surface antigen, is expressed in all B-cell lineage malignancies.;
NCI Metathesaurus CUI : CL473488;
Origin ID : C116069;
UMLS CUI : C3899817;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
