Preferred Label : Anti-CD3 OKT3/Humanized Anti-GD2 3F8 Bispecific Antibody-activated T Lymphocytes;
NCIt synonyms : Anti-CD3 x hu3F8 Bispecific Antibody Armed ATC; GD2Bi-aATC; OKT3/Humanized 3F8 Bispecific Antibody-activated T Lymphocytes; Hu3F8Bi Armed ATC;
NCIt definition : Autologous activated T cells that have been coated with bispecific antibodies (BiAb)
comprised of anti-CD3 murine monoclonal antibody OKT3 heteroconjugated to anti-GD2
humanized monoclonal antibody 3F8 (hu3F8), with potential antineoplastic and immunomodulating
activities. In vitro, T cells are exposed to OKT3, which binds to the T cell receptor-CD3
complex on the T cell surface, crosslinks the CD3 receptors and leads to T cell activation.
In turn, the hu3F8 monoclonal antibody is heteroconjugated to OKT3. Upon administration,
anti-CD3 x anti-GD2 bispecific antibody-armed activated T cells attach to GD2-expressing
tumor cells, thereby selectively cross-linking T cells and tumor cells. This results
in selective cytotoxicity towards the GD2-expressing tumor cells. In addition, cytokine
and chemokine secretion by the T cells further activates the immune system, which
leads to the recruitment and activation of cytotoxic T lymphocytes (CTLs), and additional
CTL-mediated tumor-specific cell lysis. GD2, a disialoganglioside and tumor-associated
antigen, is overexpressed in a variety of tumor cell types. CD3 is part of the functional
T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells,
and is required for signal transduction.;
NCI Metathesaurus CUI : CL473664;
Origin ID : C116330;
UMLS CUI : C3896657;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
