Preferred Label : Anti-K-RAS G12D mTCR-transduced Autologous Peripheral Blood Lymphocytes;
NCIt synonyms : Anti-KRAS G12D mTCR-transduced Autologous Peripheral Blood Lymphocytes; Anti-K-RAS G12D mTCR-transduced Autologous PBLs;
NCIt definition : Autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector
encoding for an HLA class I histocompatibility antigen A*11:01 (HLA-A1101)-restricted
murine T-cell receptor (mTCR) that recognizes the glycine (Gly, G) to aspartic acid
(Asp, D) point mutation at position 12 (G12D) variant of K-RAS (KRAS), with potential
immunomodulating and antineoplastic activities. HLA-A1101-positive PBLs are harvested
from a K-RAS G12D-expressing cancer patient and transfected with a retroviral vector
that encodes anti-K-RAS G12D mTCR. The transduced PBLs are then expanded in culture.
When reintroduced to the patient, these anti-K-RAS G12D mTCR-expressing PBLs target
and bind to K-RAS G12D-overexpressing tumor cells, which results in both cytokine
secretion, including interferon-gamma (IFN-g), and tumor cell lysis. K-RAS, a member
of the RAS family of oncogenes, serves an important role in cell signaling, division
and differentiation. Mutation of K-RAS may induce constitutive signal transduction
leading to tumor cell growth, proliferation, invasion, and metastasis.;
NCI Metathesaurus CUI : CL935986;
Origin ID : C156889;
UMLS CUI : C4723730;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
