" /> Autologous Anti-GPRC5D CAR-T Cells OriCAR-017 - CISMeF





Preferred Label : Autologous Anti-GPRC5D CAR-T Cells OriCAR-017;

NCIt synonyms : Autologous GPRC5D CAR T Cells OriCAR-017; Autologous GPRC5D-directed CAR T-cells OriCAR-017; Autologous Anti-GPRC5D CAR T-cells OriCAR-017; Autologous GPRC5D-targeted CAR T-cells OriCAR-017;

NCIt definition : A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-GPRC5D CAR-T cells OriCAR-017 specifically recognize and induce selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation. OriCAR-017 contains a signal activation domain element that may improve CAR-T cells expansion and durability.;

Molecule name : OriCAR-017; OriCAR 017;

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10/05/2025


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