" /> Varnimcabtagene Autoleucel - CISMeF





Preferred Label : Varnimcabtagene Autoleucel;

NCIt synonyms : Autologous Anti-CD19 CAR T Cells ARI-0001; CD19 CAR-T Cells ARI-0001; Autologous Anti-CD19 CAR-4-1BB-CD3zeta-expressing T-cells ARI-0001;

NCIt definition : A preparation of adult differentiated autologous T-lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv), derived from the CD19-A3B1 hybridoma, linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. The autologous T cells were stimulated with anti-CD3 and anti-CD28 antibodies, expanded with interleukin (IL) 7 (IL-7) and IL-15, and transduced with a lentiviral vector containing the CAR gene construct. Upon administration, varnimcabtagene autoleucel target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.;

UNII : PA5M8REK2P;

Molecule name : ARI-0001; PEI 19-187; ARI 0001;

NCI Metathesaurus CUI : CL1662462;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
10/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.