NCIt definition : A preparation of autologous, C-X-C chemokine receptor type 5 (CXCR 5)-modified T-lymphocytes
that have been genetically modified to express a chimeric antigen receptor (CAR) targeting
the epidermal growth factor receptor (EGFR), with potential immunostimulating and
antineoplastic activities. Upon administration, the autologous anti-EGFR CAR-transduced
CXCR 5-modified T-lymphocytes target and bind to EGFR-expressing tumor cells, thereby
inducing selective toxicity in EGFR-expressing tumor cells. EGFR, overexpressed by
a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor
angiogenesis and radio- and chemoresistance. CXCR5, and its ligand C-X-C motif chemokine
13 (CXCL13), are associated with a variety of tumors. CXCR5-CXCL13 interactions may
be involved in the regulation of lymphocyte infiltration within the tumor microenvironment
(TME).;