Preferred Label : t-lymphocytes, cytotoxic;
MeSH definition : Immunized T-lymphocytes which can directly destroy appropriate target cells. These
cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC),
in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft,
tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon
is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells
are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector
phenotypes: TC1 and TC2.;
MeSH synonym : cell mediated lympholytic cells; cytotoxic t-lymphocytes; cytotoxic t lymphocytes; cell-mediated lympholytic cell; cell, cell-mediated lympholytic; lympholytic cells, cell-mediated; cytotoxic t-lymphocyte; lympholytic cell, cell-mediated; t-lymphocyte, cytotoxic; cell-mediated lympholytic cells; T lymphocytes, cytotoxic; Cytotoxic T Lymphocyte; Lymphocyte, Cytotoxic T; T Lymphocyte, Cytotoxic; Cytotoxic T Cells; Cytotoxic T Cell; T Cell, Cytotoxic;
CISMeF synonym : Lymphocytes, Cytotoxic T; cells, cell-mediated lympholytic;
MeSH hyponym : TC1 cells; TC2 cells; Cell, TC2; Cells, TC2; TC2 Cell; Cell, TC1; Cells, TC1; TC1 Cell;
MeSH annotation : if subpopulations are discussed, coordinate IM with T-LYMPHOCYTE SUBSETS (IM);
Wikipedia link : https://en.wikipedia.org/wiki/T-lymphocytes, cytotoxic;
Origin ID : D013602;
UMLS CUI : C0039195;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- See also
- Semantic type(s)
- Cell [UMLS semantic type]
- UMLS correspondences (same concept)
Immunized T-lymphocytes which can directly destroy appropriate target cells. These
cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC),
in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft,
tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon
is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells
are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector
phenotypes: TC1 and TC2.
